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title
description
image
site name
author
updated
2026-02-20 02:49:40
raw text
Digital Development Digital Development Home Introduction Browse Search Downloads About Us WORMATLAS Home Welcome Cell Lineage Differentiation over Time, Space and Genome Elucidating how the genome shapes the regulatory landscape of cell lineage differentiation is critical for our understanding of development and in vitro cell fate engineering. However, experimental data are scarce on in vivo lineage analysis with high temporal and spatial resolution. We have recently conducted a systematic study of lineage differentiation in the C. elegans embryo. We perturbed 204 conserved and essential genes across the genome by RNAi, and analyzed the lineage of 1,368 embryos by in toto imaging and direct cell tracking [1, 2]. The Digital Development database provides the platform to browse, search and download the results. Briefly, the dataset contains the following: 1,368 cell lineages coupled with tissue marker expression. All embryos showed the em...
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2026-02-20 02:49:40
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