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title
Lost in Translation
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author
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2026-01-06 13:11:21
raw text
Lost in Translation Lost in Translation Thursday, October 4, 2012 Missing Reports: Research Biopsy in Cancer Trials A growing number of drug trials are collecting tissue to determine whether the drug hits its molecular target. These studies are called “pharmacodynamics.” And in cancer, many pharmacodynamics studies involve collection of tumor tissue through biopsies. These procedures are painful, and are performed solely to answer scientific questions. That is, they generally have no diagnostic or clinical value. As such, some commentators worry about their ethics. In a recent issue of Clinical Cancer Research , my Master’s student Gina Freeman and I report on publication practices for pharmacodynamics studies involving tumor biopsy. The basic idea is this: the ethical justification for such invasive research procedures rests on a claim that they are scientifically valuable. However, if they are never published, it is harder to argue that they have a sou...
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