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Open Flask
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2025-12-17 17:52:05
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Open Flask Thursday, February 17, 2022 A Silver Bullet for Terpene Synthesis Today, our manuscript on modular terpene synthesis enabled by mild electrochemical couplings came out in Science ! This project was a tremendous journey with lots of ups and downs, successes and setbacks, and many utterings of the phrase “back to the drawing board.” Stephen and I worked side by side on this project for about 3 years. While Stephen was the synthetic mastermind behind the routes and synthetic target selection, I was responsible for developing the electrochemistry needed to pull off the syntheses. There are lots of inventive and creative sequences to a variety of small building blocks in the SI that I implore all interested to check out! His synthetic eye was unlike many people I have seen, and it was amazing to see how he came up with incredibly short routes for some of these building blocks. For this blog post, I wanted to share some of my perspective as the one principally responsible...
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