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PLadd Science
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2026-01-27 19:25:21
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PLadd Science PLadd Science Sunday, December 29, 2013 Laura Ranum to the Rescue I previously mentioned that several different C9ORF72 ALS-FTD groups have published that there is an antisense transcript at the repeat region, but only used FISH targeting the antisense transcript. I was surprised that the claims made it through the review process, given my experience in the trinucleotide repeat field. More specifically, my most recent grants were returned with harsh reviews suggesting that antisense transcripts at repeat regions are spurious and unimportant. But the ALS-crowd embraces the prospect whole heartedly. Additionally, the ALS-crowd embraces R epeat- A ssociated N on-ATG (RAN) translation, a story that should be solely credited to Laura Ranum . OK, I am certain there are others who suggested non-ATG translation is possible. However, Laura realized it was a critical feature of trinucleotide repeat expansion diseases. As the repeat expands, there is a longer trans...
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