id
processing priority
4
site type
3 (personal blog or private political site, e.g. Blogspot, Substack, also small blogs on own domains)
review version
11
html import
20 (imported)
first seen date
2024-02-08 19:46:01
expired found date
-
created at
2024-06-01 12:34:57
updated at
2025-12-26 09:26:58
length
31
crc
8574
tld
2211
nm parts
0
nm random digits
0
nm rare letters
0
is subdomain of id
69893241 (blogspot.com)
previous id
0
replaced with id
0
related id
-
dns primary id
0
dns alternative id
0
lifecycle status
0 (unclassified, or currently active)
deleted subdomains
0
page imported products
0
page imported random
0
page imported parking
0
count skipped due to recent timeouts on the same server IP
0
count content received but rejected due to 11-799
0
count dns errors
0
count cert errors
0
count timeouts
0
count http 429
0
count http 404
0
count http 403
0
count http 5xx
0
next operation date
-
server bits
—
server ip
-
mp import status
20
mp rejected date
-
mp saved date
-
mp size orig
329774
mp size raw text
63142
mp inner links count
343
mp inner links status
20 (imported)
title
Practical Fragments
description
This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments.
image
site name
author
updated
2025-12-14 00:38:11
raw text
Practical Fragments Practical Fragments This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments. 05 February 2024 Fragment screening across the proteome, industrialized Last week we discussed covalent fragment screens against isolated enzymes, which can be very effective. But screening in cells or cell lysates preserves proteins in a more physiological environment and allows many proteins across the proteome to be screened simultaneously. In 2016 we wrote about covalent screens in human cell lysates which identified fragment hits for 758 cysteine residues in 637 proteins. Mass spectrometry techniques have improved since then in terms of both speed and sensitivity, as illustrated in a new Cell Chem. Biol. paper from Steve Gygi, Qing Yu, and collaborators at Harvard Medical School and Biogen. (Disclosure: Steve Gygi is on the Scientific Advisory Board of my current company, Frontier Med...
redirect type
0 (-)
block type
0 (no issues)
detected language
1 (English)
category id
index version
2025110801
spam phrases
0
text nonlatin
0
text cyrillic
0
text characters
50251
text words
9390
text unique words
2457
text lines
1613
text sentences
473
text paragraphs
150
text words per sentence
19
text matched phrases
15
text matched dictionaries
11
links self subdomains
0
links other subdomains
5 - alphafold.ebi.ac.uk, checkmyblob.bioreproducibility.org, link.springer.com, openinnovation.astrazeneca.com, advisor.docking.org
links other domains
17 - rscbmcs.org, drugdiscoverychemistry.com, novalix-conferences.org, fbdddownunder.com.au, fbldconference.org, discoveryontarget.com, rcsb.org, pdb-redo.eu, endpts.com, fiercepharma.com, dndi.org, science.org, chemicalprobes.org, netvibes.com
links spam adult
0
links spam random
0
links spam expired
0
links ext activities
38
links ext ecommerce
0
links ext finance
0
links ext crypto
0
links ext booking
0
links ext news
2
links ext leaks
0
links ext ugc
81 - blogger.com, en.wikipedia.org, fbdd-lit.blogspot.com, linkedin.com, twitter.com
links ext klim
0
links ext generic
3
dol status
0
dol updated
2025-12-14 00:38:11
rss status
32 (unknown)
rss found date
2024-02-15 15:38:06
rss size orig
248453
rss items
25
rss spam phrases
0
rss detected language
1 (English)
inbefore feed id
-
inbefore status
0 (new)
sitemap path
sitemap status
30 (processing completed, results pushed to table crawler_sitemaps.ext_domain_sitemap_lists)
sitemap review version
1
sitemap urls count
991
sitemap urls adult
0
sitemap filtered products
0
sitemap filtered videos
0
sitemap found date
2024-02-25 14:30:06
sitemap process date
2024-12-02 09:17:59
sitemap first import date
-
sitemap last import date
-