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title
HPTLC Detects Diphenhydramine & Naproxen in Tablets - Creative Proteomics Blog
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 IntroductionRecently, the high performance thin layer chromatography---HPTLC, as a rapid and simple method, is used to determine DPH and NPS from pharmaceutical preparation simultaneously. Diphenhydramine hydrochloride is an antihistamines, which appear to compete with histamine for cell receptor sites on effector cell, with anticholinergic and seda-tive effects. And Naproxen sodium is 2-propanoate sodium.MaterialsChemicals and reagentsPurifying DPH and NPS and receiving as a gift sample from Souvin Pharmaceuticals and Rubicon Pharmaceuticals, respectively. And then combining and formulating 25mg of DPH and 200mg of NPS. The solvents, including toluene, methanol and glacial acetic acid, should all be of AR grade.InstrumentationMicrosyrine, which should be precoated with silica gel 60 F254 glass plates, Camag 10 μL sample syringe, Camag Linomat V automatic sample applicator, Camag twin through chamber 10 x 10 cm, TLC ...
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